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ABMM PDF Practice Q&A's

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American Society of Microbiology ABMM Sample Questions:

1. Besides traditional Giemsa-stained thick and thin blood smears, which diagnostic approach is commonly employed as a rapid diagnostic test (RDT) for malaria detection, particularly in resource-limited settings?

A) PCR amplification of Plasmodium 18S rRNA gene directly from saliva
B) Serological detection of anti-Plasmodium IgG antibodies
C) Quantitative Buffy Coat (QBC) analysis
D) Immunochromatographic assays detecting Plasmodium-specific antigens (e.g., HRP2, pLDH)


2. A patient with a history of exposure to bats in a cave develops progressive neurological symptoms, including hydrophobia. The MOST likely viral etiology is:

A) Rabies virus
B) Japanese encephalitis virus
C) West Nile virus
D) Herpes simplex virus encephalitis


3. A research laboratory is investigating the mechanism of action of a novel antiviral compound that inhibits the replication of a specific RNA virus. They find that the compound binds directly to the viral RNA-dependent RNA polymerase, preventing its elongation activity. This mechanism is most similar to that of:

A) Acyclovir
B) Ribavirin
C) Oseltamivir
D) Interferon-beta


4. Which of the following organisms is an obligate intracellular bacterium transmitted by arthropod vectors and is a common cause of Rocky Mountain Spotted Fever?

A) Borrelia burgdorferi
B) Coxiella burnetii
C) Rickettsia rickettsii
D) Chlamydia trachomatis


5. Which of the following viruses is an enveloped, double-stranded DNA virus known to cause latent infections often reactivated during immunosuppression?

A) Rotavirus
B) Cytomegalovirus (CMV)
C) Influenza A virus
D) Poliovirus


Solutions:

Question # 1
Answer: D
Question # 2
Answer: A
Question # 3
Answer: B
Question # 4
Answer: C
Question # 5
Answer: B

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